Compliance Enhancing Packaging
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non-compliance is the biggest problem in patient care worldwide. Many
factors are attributed to non-compliance including improper labeling, memory
problems in elderly and child-resistant packaging which the elderly find
difficult to use, etc. This warrants the need to develop compliance
enhancing formats which help patients to take their medications properly.
People from all focus group have come to the conclusion that compliance
packaging is highly effective in helping patients manage their medication
regimens. Another reason for increasing interest in compliance packaging is
the transition of some drugs from multidose to one dose per day or even one
dose a week. With such modified dosage forms compliance becomes more
critical because skipping a single doze could turn crucial.
The most significant compliance packs are unit-dose blisters, especially
carded blisters, which have the advantage of providing sufficient space for
instructions on how and when to take medication.
One of the best compliance feature would be a chart or a device that
indicates the dosage used and when the dosage was taken. The use of
heat-seal cards enhance the ability as they allow a large billboard for
displaying time and sequence instructions. Bar codes are becoming essential
in case of multi-dose and multi-strength packaging. They help to identify
the correct medication for the correct patient and also to verify their
correct strengths. Clinical trial packagings are also compliance dependant.
Another feature is child-resistant senior friendly compliance enhancing
packaging. Such features are complicated as sometimes child-resistant senior
friendly (CR-SF) requirement and compliance requirements are complimentary.
In United States of America, developing compliance packaging is tricky
because of the CR-SF regulations. However, this can be achieved using
secondary packaging, such as cards.
Unit Dose Blister
Studies indicate that unit dose calendar packs are more compliance
enhancing as compared to bottles or other non-calendar packs. Blister
packaging with calendar-like features can enhance compliance.
In case of bottles with outserts, manufacturers are not sure whether their
consumers actually read the instructions. If they use a fold over card with
a blister, it is easier for them to get their message across to the end
user. If the cost of the package is not a problem, then newer formats of a
blister within a die-cut board are compliant, child-resistant and senior
Insurance companies and managed care organizations are not the only ones to
bear the economic burden from pharmaceutical non-compliance; every person
has a share in it, in the form of higher taxes, premiums and lost
productivity. For manufacturers, these are value added services, as better
compliance will lead to higher sales. In case of patient, being compliant
will decrease their chances of being admitted to hospitals. Also compliance
helps to reduce health care cost considerably. Thus, the day is not far when
consumer will have a choice when they get their prescriptions filled -
either the standard cap and vial format or a compliance style unit dose
package attributed - which will help them to take their medications